Ganesh A Thakur Selected Research

4- (4- bromophenyl)- 3a,4,5,9b- tetrahydro- 3H- cyclopenta(c)quinoline- 8- sulfonamide

1/2023	GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation.
4/2021	Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107.
1/2021	The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages.
1/2018	Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states.
1/2016	The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.

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Ganesh A Thakur Research Topics

Disease

20	Pain (Aches) 05/2024 - 12/2002
11	Hyperalgesia 01/2022 - 11/2008
9	Neuralgia (Stump Neuralgia) 01/2022 - 11/2008
8	Inflammation (Inflammations) 05/2024 - 11/2008
6	Hypothermia 11/2022 - 06/2011
5	Hypersensitivity (Allergy) 01/2020 - 11/2008
4	Glaucoma 01/2022 - 07/2005
4	Peripheral Nervous System Diseases (PNS Diseases) 12/2020 - 11/2008
3	Schizophrenia (Dementia Praecox) 01/2023 - 01/2021
3	Chronic Pain 01/2020 - 04/2015
3	Nausea 03/2013 - 03/2008
2	Hyperoxia 01/2023 - 01/2021
2	Catalepsy 11/2022 - 08/2013
2	Opioid-Related Disorders (Opiate Addiction) 11/2022 - 01/2022
2	Absence Epilepsy (Childhood Absence Epilepsy) 06/2022 - 01/2021
2	Seizures (Absence Seizure) 01/2022 - 01/2021
2	Immune System Diseases (Immune Disorders) 01/2022 - 11/2008
2	Huntington Disease (Huntington's Disease) 01/2022 - 01/2019
2	Epilepsy (Aura) 01/2022 - 01/2021
2	Multiple Sclerosis 04/2021 - 07/2005
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2020 - 01/2018
2	Abdominal Pain (Pain, Abdominal) 11/2019 - 10/2018
2	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 11/2019 - 10/2018
2	Neoplasms (Cancer) 10/2019 - 03/2019
2	Ataxia (Dyssynergia) 01/2017 - 06/2011
2	Vomiting 03/2013 - 03/2008
1	Substance-Related Disorders (Drug Abuse) 01/2024
1	Virus Diseases (Viral Diseases) 01/2023
1	Ventilator-Associated Pneumonia 01/2023
1	Lung Injury 01/2023
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2022
1	Sciatic Neuropathy (Lesion of Sciatic Nerve) 01/2022
1	Neuroinflammatory Diseases 04/2021
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2021
1	COVID-19 01/2021
1	Tobacco Use Disorder (Nicotine Dependence) 01/2021
1	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2021
1	Psychotic Disorders (Schizoaffective Disorder) 01/2021

Drug/Important Bio-Agent (IBA)

18	CannabinoidsIBA 01/2022 - 03/2008
12	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2024 - 03/2013
11	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 05/2024 - 04/2015
8	Paclitaxel (Taxol)FDA LinkGeneric 01/2020 - 11/2008
7	Formaldehyde (Formol)FDA Link 01/2024 - 04/2015
7	Proteins (Proteins, Gene)FDA Link 01/2024 - 12/2002
6	3- (1,1- dimethyl- heptyl)- 1- hydroxy- 9- methoxy- benzo(c)chromen- 6- oneIBA 01/2022 - 06/2011
6	3- (2- nitro- 1- phenylethyl)- 2- phenyl- 1H- indoleIBA 01/2022 - 11/2018
5	4- (4- bromophenyl)- 3a,4,5,9b- tetrahydro- 3H- cyclopenta(c)quinoline- 8- sulfonamideIBA 01/2023 - 01/2016
4	CytokinesIBA 02/2024 - 03/2012
4	Morphine (MS Contin)FDA LinkGeneric 01/2024 - 02/2013
4	EndocannabinoidsIBA 01/2022 - 03/2012
4	Analgesics (Analgesic Drugs)IBA 01/2020 - 01/2017
4	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 01/2020 - 07/2005
3	Opioid Analgesics (Opioids)IBA 11/2022 - 02/2013
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 04/2021 - 10/2015
3	Dizocilpine Maleate (Dizocilpine)IBA 01/2021 - 10/2015
3	Freund's AdjuvantIBA 11/2018 - 10/2015
3	2- ((1H- benzo(d)(1,2,3)triazol- 5- ylamino)methyl)- 4,6- dichlorophenolIBA 01/2017 - 10/2015
3	9- (hydroxymethyl)- 3- (1- adamantyl)hexahydrocannabinolIBA 08/2013 - 01/2013
3	RimonabantIBA 03/2013 - 03/2008
3	AM4113IBA 02/2013 - 03/2008
2	Cholinergic Agents (Cholinergics)IBA 02/2024 - 04/2021
2	Naloxone (Narcan)FDA LinkGeneric 01/2024 - 01/2020
2	Oxygen (Dioxygen)IBA 01/2023 - 01/2021
2	2-phenylindoleIBA 01/2022 - 11/2021
2	AM 1241IBA 01/2022 - 03/2012
2	Nicotine FDA Link 01/2021 - 10/2019
2	Interleukin-10 (Interleukin 10)IBA 12/2020 - 03/2012
2	LigandsIBA 01/2020 - 01/2014
2	AM9405IBA 11/2019 - 10/2018
2	Serotonin (5 Hydroxytryptamine)IBA 11/2019 - 10/2018
2	Antineoplastic Agents (Antineoplastics)IBA 10/2019 - 11/2008
2	1,4- diazabicyclo(3.2.2)nonan- 4- yl(5- (3- (trifluoromethyl)phenyl)furan- 2- yl)methanoneIBA 01/2018 - 04/2015
2	Mesylates (Mesylate)IBA 02/2013 - 01/2013
1	SaltsIBA 05/2024
1	3-(2,4-dimethoxybenzylidene)anabaseineIBA 01/2023
1	HMGB1 Protein (HMG1)IBA 01/2023
1	Superoxide DismutaseIBA 01/2023
1	Superoxides (Superoxide)IBA 01/2023
1	3- (2- hydroxy- 4- (1,1- dimethylheptyl)phenyl)- 4- (3- hydroxypropyl)cyclohexanolIBA 11/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	ABX-1431IBA 01/2022
1	TRPV1 receptorIBA 01/2022
1	ElementsIBA 01/2022
1	CationsIBA 01/2022
1	Antipsychotic Agents (Antipsychotics)IBA 04/2021
1	Heme Oxygenase-1IBA 01/2021
1	Superoxide Dismutase-1IBA 01/2021
1	Actins (F Actin)IBA 01/2021
1	Glutamic Acid (Glutamate)FDA Link 01/2021
1	Sucrose (Saccharose)IBA 01/2021
1	Protein Isoforms (Isoforms)IBA 01/2021
1	CannabidiolIBA 01/2021
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021
1	GTP-Binding Proteins (G-Protein)IBA 01/2021
1	salicylhydroxamic acid (SHAM)IBA 12/2020

Therapy/Procedure

6	Therapeutics 05/2024 - 10/2019
5	Drug Therapy (Chemotherapy) 01/2020 - 09/2012
3	Analgesia 08/2013 - 01/2013
1	Induced Hyperthermia (Thermotherapy) 01/2022
1	Self Administration (Administration, Self) 01/2021